Diversity of T cell epitopes in Plasmodium falciparum circumsporozoite protein likely due to protein-protein interactions.

Circumsporozoite protein (CS) is a leading vaccine antigen for falciparum green microsuede fabric malaria, but is highly polymorphic in natural parasite populations.The factors driving this diversity are unclear, but non-random assortment of the T cell epitopes TH2 and TH3 has been observed in a Kenyan parasite population.The recent publication of

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Heterologous versus homologous COVID-19 booster vaccinations for adults: systematic review with meta-analysis and trial sequential analysis of randomised clinical trials

Abstract Background To combat coronavirus disease 2019 (COVID-19), booster vaccination strategies are important.However, the optimal administration stor trebolle of booster vaccine platforms remains unclear.Herein, we aimed to assess the benefits and harms of three or four heterologous versus homologous booster regimens.Methods From November 3 2022

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